BB ของอ ม หร อจะส BB ของ CRH
|
|
- Rhoda Barber
- 5 years ago
- Views:
Transcription
1 Company LOGO A systematic review of selective and non-selective beta blockers for prevention of vascular events in patients with acute coronary syndrome or heart failure Supattra Bangpa ID Kulnipa Boosri ID Faculty of Pharmacy Naresuan University ambulatory clerkchip : 12 November 2010
2
3 BB ของอ ม หร อจะส BB ของ CRH
4 Company LOGO A systematic review of selective and non-selective beta blockers for prevention of vascular events in patients with acute coronary syndrome or heart failure Supattra Bangpa ID Kulnipa Boosri ID Faculty of Pharmacy Naresuan University ambulatory clerkchip : 12 November 2010
5 Outline Introduction Methods Results Conclusions Evaluation
6 Introduction Beta-adrenergic receptor blocking recommended for the treatment of patients with ACS or HF inhibit sympathetic activity: decrease mortality 1 blocker: higher affinity for blocker: affinity for 1 = 2
7 Introduction Clinical effects of beta-adrenergic blockade in chronic heart failure: a meta-analysis of double-blind, placebo-controlled, randomized trials. Circulation. 1998;98: Comparative effects of carvedilol and metoprolol on left ventricular ejection fraction in heart failure: results of a meta-analysis Am Heart J. 2001;141: blocker have better effect on total mortality and cardiovascular morbidity in patients with ACS and HF
8 Objective To assess the influence of b2-receptor occurrence of vascular events and on all cause mortality in patients with acute coronary syndrome (ACS) or heart failure (HF ).
9 Methods literature search of Medline, EMBASE and the Cochrane Central Register RCT published from 1981-june 2009 effects of 1 and 1+2 blockers for secondary prevention in patients with ACS or HF studies had a minimum treatment period of 3 mo. primary outcomes: 1. all-cause mortality 2. vascular events
10 Methods limited to studies of humans and were not restricted to English language studies assessing b-blockers with intrinsic sympathicomimetic, class-iii antiarrhythmic or partial agonist activity, were excluded articles was reviewed by two independently authors disagreement was resolved by third reviewer
11 Methods strokes vascular events myocardial infarctions fatal pulmonary embolisms venous thromboembolic events
12 Statistical analysis Relative risks (RR) and 95% confidence intervals (95% CI) DerSimonian and Laird random-effect model Test for heterogeneity:x 2 and I 2 Sensitivity analyses
13 Results identified & screened n=4258 retrieved for detailed n=85 excluded by using the predefined n=4173 manual reviewed n=2 excluded after full article screening n=48 included in the review n=33 Duplicates with additional information n=6
14 Summary of treatment Treatment Target dose percent Metoprolol mg 33% Carvidilol 25 mg bid 45% Atenolol 50 mg bid 3% Betaxolol 20 mg bid 3% Propanolol mg 9% Timolol 10 mg bid 3% Bisoprolol 5-10 mg 6% Bucindolol 50 mg bid 3% Nebivolol 10 mg 3%
15 Results 14%
16 Results Total mortality : β1 blocker in patient ACS
17 Results Total mortality : β1+2 blocker in patient ACS 27%
18 Results Vascular events: β1 blocker in patient ACS
19 Results Vascular events: β1+2 blocker in patient ACS 29% 31%
20 Results Total mortality: β1 blocker in patient HF 24%
21 Results Total mortality: β1+2 blocker in patient HF 25% 23%
22 Results Vascular events: β1 blocker in patient HF
23 Results Vascular events: β1+2 blocker in patient HF
24 Conclusion Additional b2-receptor blockade may be more effective than b1-receptor blockade alone in preventing total mortality and vascular events in patients with ACS or, to a lesser extent, HF. However, only a few studies directly compared b blockers, and indirect comparisons were subject to heterogeneity, which weakens firm conclusions.
25 Evaluation
26 Title Impact factor: 1.20
27 Abstract
28 Method Study selection Randomised controlled trial Keyword; RCT, acute coronary syndrome, congestive heart failure, heart muscle ischemia, etc. Limited to studies of human and not restricted to English language Reviewed by two authors third reviewer Assess the agreement between reviewers: kappa (K)statistic
29 Method Data extraction and quality assessment Baseline characteristics NYHA Composite endpoint study using adequate treatment allocation sequence, proper concealment, binding patient and investigator, completeness of follow-up JADAD scale
30 Method Statistical analysis Potential biases of comparison between different studies. Analysed by pooling the result Relative risk (RR) and 95% confidence interval DerSimonian and Laird random-effects model Heterogeneity between studies Sensitivity analyses
31 การนาไปประย กต ใช การศ กษาน ม ความน าเช อถ อ สามารถนาไปอ างอ งใช ก บผ ป วย ACS และ HF ได เน องจากผลการศ กษา ด งกล าวบ งบอกว าการได ร บ B1+2 ช วยลดความเส ยงต อ การเส ยช ว ตและการเก ด vascular event ได แต อย างไรก ตามการพ จารณาเล อกยาให ผ ป วยต องด ความเหมาะสม และยาท ม อย ในโรงพยาบาลน นๆเป นหล ก
32 Thank you for your attention ^-^ Company LOGO
Heart failure. Complex clinical syndrome. Estimated prevalence of ~2.4% (NHANES)
Heart failure Complex clinical syndrome caused by any structural or functional impairment of ventricular filling or ejection of blood Estimated prevalence of ~2.4% (NHANES) Etiology Generally divided into
More informationCKD Satellite Symposium
CKD Satellite Symposium Recommended Therapy by Heart Failure Stage AHA/ACC Task Force on Practice Guideline 2001 Natural History of Heart Failure Patients surviving % Mechanism of death Sudden death 40%
More informationPharmacist's Role in Medication Safety : What We Can Learn from Experiences in Ambulatory Clinic
Pharmacist's Role in Medication Safety : What We Can Learn from Experiences in Ambulatory Clinic ภญ. ธศ กานต แช มช อย ภญ. แอนน ไพศาลส ร ก ล กล มงานเภส ชกรรม โรงพยาบาลจ ฬาลงกรณ The median ADE incidence
More informationMetoprolol Succinate SelokenZOC
Metoprolol Succinate SelokenZOC Blood Pressure Control and Far Beyond Mohamed Abdel Ghany World Health Organization - Noncommunicable Diseases (NCD) Country Profiles, 2014. 1 Death Rates From Ischemic
More informationBeta-blockers in heart failure: evidence put into practice
Beta-blockers in heart failure: evidence put into practice John McMurray Professor of Medical Cardiology, University of Glasgow & Consultant Cardiologist,Western Infirmary, Glasgow, UK Eugene Braunwald
More informationManagement of new onset atrial fibrillation McNamara R L, Bass E B, Miller M R, Segal J B, Goodman S N, Kim N L, Robinson K A, Powe N R
Management of new onset atrial fibrillation McNamara R L, Bass E B, Miller M R, Segal J B, Goodman S N, Kim N L, Robinson K A, Powe N R Authors' objectives To synthesise the evidence that exists to guide
More informationUnderstanding and Development of New Therapies for Heart Failure - Lessons from Recent Clinical Trials -
Understanding and Development of New Therapies for Heart Failure - Lessons from Recent Clinical Trials - Clinical trials Evidence-based medicine, clinical practice Impact upon Understanding pathophysiology
More informationReliability and Validity of Long Case and Short Case in Internal Medicine Board Certification Examination
Reliability and Validity of Long Case and Short Case in Internal Medicine Board Certification Examination Nitipatana Chierakul MD*, **, Somwang Danchaivijitr MD*, **, Paka Kontee BBA*, Chana Naruman MSc**
More informationOptimal Adrenergic Blockades in Heart Failure. Jae-Joong Kim MD, PhD Asan Medical Center, University of Ulsan, Seoul, Korea
Optimal Adrenergic Blockades in Heart Failure Jae-Joong Kim MD, PhD Asan Medical Center, University of Ulsan, Seoul, Korea Contents Harmful effects of adrenergic system in heart failure Clinical studies
More informationBeta-blockers for hypertension(review)
Cochrane Database of Systematic Reviews Beta-blockers for hypertension(review) WiysongeCS,BradleyHA,VolminkJ,MayosiBM,OpieLH Wiysonge CS, Bradley HA, Volmink J, Mayosi BM, Opie LH. Beta-blockers for hypertension.
More informationComparative Study between Preoperative and Postoperative Histologic Grading in Adenocarcinoma of the Colon and Rectum
Comparative Study between Preoperative and Postoperative Histologic Grading in Adenocarcinoma of the Colon and Rectum Bunlue Chaleoykitti MD* * Division of Colorectal Surgery, Department of Surgery, Phramongkutklao
More informationOnline Appendix (JACC )
Beta blockers in Heart Failure Collaborative Group Online Appendix (JACC013117-0413) Heart rate, heart rhythm and prognostic effect of beta-blockers in heart failure: individual-patient data meta-analysis
More informationDrug Class Review on Beta Adrenergic Blockers
Drug Class Review on Beta Adrenergic Blockers Final Report May 2005 The purpose of this report is to make available information regarding the comparative effectiveness and safety profiles of different
More informationEfficacy of beta-blockers in heart failure patients with atrial fibrillation: An individual patient data meta-analysis
Efficacy of beta-blockers in heart failure patients with atrial fibrillation: An individual patient data meta-analysis Dipak Kotecha, MD PhD on behalf of the Selection of slides presented at the European
More informationObservational study II
Observational study II (QUANTITATIVE METHOD IV) หล กส ตรเวชศาสตร ช มชน RACM 302 1 AIMS Observational study and analytic study designs : Case-control study Cross-sectional study Ecological study Calculate
More informationEvidence Supporting Post-MI Use of
Addressing the Gap in the Management of Patients After Acute Myocardial Infarction: How Good Is the Evidence Supporting Current Treatment Guidelines? Michael B. Fowler, MB, FRCP Beta-adrenergic blocking
More informationDRUG CLASSES BETA-ADRENOCEPTOR ANTAGONISTS (BETA-BLOCKERS)
DRUG CLASSES BETA-ADRENOCEPTOR ANTAGONISTS (BETA-BLOCKERS) Beta-blockers have been widely used in the management of angina, certain tachyarrhythmias and heart failure, as well as in hypertension. Examples
More informationDrug Class Review On Beta Adrenergic Blockers
Drug Class Review On Beta Adrenergic Blockers DRAFT DO NOT QUOTE OR CITE Kim Peterson, MS Mark Helfand, MD, MPH Produced by Oregon Evidence-based Practice Center Oregon Health & Science University 3181
More informationExecutive Summary. Different antihypertensive drugs as first line therapy in patients with essential hypertension 1
IQWiG Reports Commission No. A05-09 Different antihypertensive drugs as first line therapy in patients with essential hypertension 1 Executive Summary 1 Translation of the executive summary of the final
More informationCritical Appraisal of a Meta-Analysis: Rosiglitazone and CV Death. Debra Moy Faculty of Pharmacy University of Toronto
Critical Appraisal of a Meta-Analysis: Rosiglitazone and CV Death Debra Moy Faculty of Pharmacy University of Toronto Goal To provide practitioners with a systematic approach to evaluating a meta analysis
More informationBeta blockers as cardioprotective agents: Part II Focus on prevention of sudden
Beta blockers as cardioprotective agents: Part II Focus on prevention of sudden cardiac death Sidney Goldstein, MD From the Division of Cardiovascular Medicine, Henry Ford Heart and Vascular Institute,
More informationHeart Failure and Cardiomyopathy Center, Division of Cardiology, North Shore University Hospital, Manhasset, NY
NEUROHORMONAL ANTAGONISTS IN THE POST-MI PATIENT New Evidence from the CAPRICORN Trial: The Role of Carvedilol in High-Risk, Post Myocardial Infarction Patients Jonathan D. Sackner-Bernstein, MD, FACC
More informationDr. Khan Abul Kalam Azad Associate Professor Department of Medicine SZRMC, Bogra
Dr. Khan Abul Kalam Azad Associate Professor Department of Medicine SZRMC, Bogra Beta-blockers were used in several longterm morbidity and trials in the treatment of hypertension, either alone or in comparison
More informationAmerican Journal of Internal Medicine
American Journal of Internal Medicine 2016; 4(3): 49-59 http://www.sciencepublishinggroup.com/j/ajim doi: 10.11648/j.ajim.20160403.12 ISSN: 2330-4316 (Print); ISSN: 2330-4324 (Online) The Effect of Dose-Reduced
More informationHeart Failure Update John Coyle, M.D.
Heart Failure Update 2011 John Coyle, M.D. Causes of Heart Failure Anderson,B.Am Heart J 1993;126:632-40 It It is now well-established that at least one-half of the patients presenting with symptoms and
More informationHeart rate lowering treatment in chronic heart failure
Heart rate lowering treatment in chronic heart failure Jaromir Hradec 3rd Dept. Med., Charles Univ., Prague Czech Republic Things we knew, things we did Things we have learnt, things we should do What
More informationSemilogarithmic relation between rest heart rate and life expectancy
The importance of heart rate in heart failure Karl Swedberg Professor of Medicine Department t of emergency and cardiovascular medicine i Sahlgrenska Academy University of Gothenburg, Sweden karl.swedberg@gu.se
More informationSystematic Review & Course outline. Lecture (20%) Class discussion & tutorial (30%)
Systematic Review & Meta-analysisanalysis Ammarin Thakkinstian, Ph.D. Section for Clinical Epidemiology and Biostatistics Faculty of Medicine, Ramathibodi Hospital Tel: 02-201-1269, 02-201-1762 Fax: 02-2011284
More informationPrimary Research Study Methodology II
Primary Research Study Methodology II Patompong Ungprasert, MD, MS Clinical Epidemiology Unit, Department of Research and Development Faculty of Medicine Siriraj Hospital, Mahidol University Patompong.Unp@Mahidol.ac.th
More informationStudy Exposures, Outcomes:
GSK Medicine: Coreg IR, Coreg CR, and InnoPran Study No.: WWE111944/WEUSRTP3149 Title: A nested case-control study of the association between Coreg IR and Coreg CR and hypersensitivity reactions: anaphylactic
More informationDeep vein thrombosis and its prevention in critically ill adults Attia J, Ray J G, Cook D J, Douketis J, Ginsberg J S, Geerts W H
Deep vein thrombosis and its prevention in critically ill adults Attia J, Ray J G, Cook D J, Douketis J, Ginsberg J S, Geerts W H Authors' objectives To systematically review the incidence of deep vein
More informationThe Hearth Rate modulators. How to optimise treatment
The Hearth Rate modulators How to optimise treatment Munich, ESC Congress 2012 Prof. Luigi Tavazzi GVM Care&Research E.S. Health Science Foundation Cotignola, IT Disclosure Cooperation with: Servier, Medtronic,
More informationPolypharmacy - arrhythmic risks in patients with heart failure
Influencing sudden cardiac death by pharmacotherapy Polypharmacy - arrhythmic risks in patients with heart failure Professor Dan Atar Head, Dept. of Cardiology Oslo University Hospital Ullevål Norway 27.8.2012
More informationSystematic reviews and meta-analyses of observational studies (MOOSE): Checklist.
Systematic reviews and meta-analyses of observational studies (MOOSE): Checklist. MOOSE Checklist Infliximab reduces hospitalizations and surgery interventions in patients with inflammatory bowel disease:
More informationA SYSTEMATIC REVIEW OF THE BLOOD PRESSURE LOWERING EFFICACY OF BETA BLOCKERS FOR PRIMARY HYPERTENSION WAN KI WONG
A SYSTEMATIC REVIEW OF THE BLOOD PRESSURE LOWERING EFFICACY OF BETA BLOCKERS FOR PRIMARY HYPERTENSION by WAN KI WONG B.A., The Ohio State University, 2002 B.Sc., The Ohio State University, 2006 A THESIS
More informationThe CARI Guidelines Caring for Australasians with Renal Impairment. Blood Pressure Control role of specific antihypertensives
Blood Pressure Control role of specific antihypertensives Date written: May 2005 Final submission: October 2005 Author: Adrian Gillian GUIDELINES a. Regimens that include angiotensin-converting enzyme
More informationβ adrenergic blockade, a renal perspective Prof S O McLigeyo
β adrenergic blockade, a renal perspective Prof S O McLigeyo Carvedilol Third generation β blocker (both β 1 and β 2 ) Possesses α 1 adrenergic blocking properties. β: α blocking ratio 7:1 to 3:1 Antioxidant
More informationGuideline of status epilepticus management 2017
Guideline of status epilepticus management 2017 Kanitpong Phabphal Professor of Neurology Guideline 1966 to Jan 2005 European Foundation Neurology Society 2010 Hong Kong Epilepsy Society Society 2017 Published
More informationTherapeutic Targets and Interventions
Therapeutic Targets and Interventions Ali Valika, MD, FACC Advanced Heart Failure and Pulmonary Hypertension Advocate Medical Group Midwest Heart Foundation Disclosures: 1. Novartis: Speaker Honorarium
More informationsurgery: A systematic review and meta-analysis protocol
Title Perioperative dexmedetomidine and outcomes after adult cardiac surgery: A systematic review and meta-analysis protocol Registration PROSPERO (registered December 8 th, 2015) Authors David McIlroy
More informationBeta-Blockers and Outcome in Heart Failure and Atrial Fibrillation A Meta-Analysis
JACC: Heart Failure Vol. 1, No. 1, 2013 Ó 2013 by the American College of Cardiology Foundation ISSN 2213-1779/$36.00 Published by Elsevier Inc. http://dx.doi.org/10.1016/j.jchf.2012.09.002 CLINICAL RESEARCH
More informationTrials Enrolled subjects Findings Fox et al. 2014, SIGNIFY 1
Appendix 5 (as supplied by the authors): Published trials on the effect of ivabradine on outcomes including mortality in patients with different cardiovascular diseases Trials Enrolled subjects Findings
More informationEffects of heart rate reduction with ivabradine on left ventricular remodeling and function:
Systolic Heart failure treatment with the If inhibitor ivabradine Trial Effects of heart rate reduction with ivabradine on left ventricular remodeling and function: results of the SHIFT echocardiography
More informationORIGINAL ARTICLES. Pentoxifylline for heart failure: a systematic review STUDENT PAPER. Kathryn Batchelder, Bongani M Mayosi
STUDENT PAPER Pentoxifylline for heart failure: a systematic review Kathryn Batchelder, Bongani M Mayosi Background. Recent trials have indicated a beneficial effect of pentoxifylline on measures of inflammation
More informationExtracardiac Conduit versus Lateral Tunnel for Total Cavopulmonary Connections
Cases Report Extracardiac Conduit versus Lateral Tunnel for Total Cavopulmonary Connections Sukasom Attanavanich MD*, Panuwat Lertsithichai MD* * Cardiovascular Thoracic Unit, Division of Surgery, Faculty
More informationStatistical challenges of meta-analyses of randomised clinical trials in a regulatory setting
Statistical challenges of meta-analyses of randomised clinical trials in a regulatory setting Frank Pétavy ISCTM 14th Annual Scientific Meeting, Washington D.C. Presented by Frank Pétavy on 21 February
More informationHeart Failure (HF) Treatment
Heart Failure (HF) Treatment Heart Failure (HF) Complex, progressive disorder. The heart is unable to pump sufficient blood to meet the needs of the body. Its cardinal symptoms are dyspnea, fatigue, and
More informationPROSPERO International prospective register of systematic reviews
PROSPERO International prospective register of systematic reviews Prophylactic cranial irradiation in patients with non-small-cell lung cancer: a systematic review and meta-analysis of randomized controlled
More informationControversies in Cardiac Pharmacology
Controversies in Cardiac Pharmacology Thomas D. Conley, MD FACC FSCAI Disclosures I have no relevant relationships with commercial interests to disclose. 1 Doc, do I really need to take all these medicines?
More informationSystematic review with multiple treatment comparison metaanalysis. on interventions for hepatic encephalopathy
Systematic review with multiple treatment comparison metaanalysis on interventions for hepatic encephalopathy Hepatic encephalopathy (HE) is a reversible neuropsychiatric syndrome associated with severe
More informationDronedarone for the treatment of non-permanent atrial fibrillation
Dronedarone for the treatment of non-permanent atrial Issued: August 2010 last modified: December 2012 guidance.nice.org.uk/ta197 NICE has accredited the process used by the Centre for Health Technology
More informationProgram Metrics. New Unique ID. Old Unique ID. Metric Set Metric Name Description. Old Metric Name
Program Metrics The list below includes the metrics that will be calculated by the PINNACLE Registry for the outpatient office setting. These include metrics for, Atrial Fibrillation, Hypertension and.
More informationMEDICAL MANAGEMENT OF PATIENTS WITH HEART FAILURE AND REDUCED EJECTION FRACTION
MEDICAL MANAGEMENT OF PATIENTS WITH HEART FAILURE AND REDUCED EJECTION FRACTION FRANCIS X. CELIS, D.O. OPSO FALL CONFERENCE PORTLAND, OR 16 SEPTEMBER 2017 OVERVIEW What are the ACC/AHA Stages of HF? What
More informationDrug Class Review on Calcium Channel Blockers
Drug Class Review on UPDATED FINAL REPORT #1 April 2004 Marian S. McDonagh, PharmD Karen B. Eden, PhD Kim Peterson, MS Oregon Evidence-based Practice Center Oregon Health & Science University Table of
More informationGRADE for reducing adversegrade for reducing adverse outcomes. outcomes
outcomes GRADE for reducing adversegrade for reducing adverse outcomes actions to reduce adverse outcomes should be based on confidence in estimates of effect GRADE provides detailed guidance for assessing
More informationThe benefit of treatment with -blockers in heart failure is
Heart Rate and Cardiac Rhythm Relationships With Bisoprolol Benefit in Chronic Heart Failure in CIBIS II Trial Philippe Lechat, MD, PhD; Jean-Sébastien Hulot, MD; Sylvie Escolano, MD, PhD; Alain Mallet,
More informationPharmacological Treatment for Chronic Heart Failure. Dr Elaine Chau HK Sanatorium & Hospital, Hong Kong 3 August 2014
Pharmacological Treatment for Chronic Heart Failure Dr Elaine Chau HK Sanatorium & Hospital, Hong Kong 3 August 2014 1 ACC/AHA 2005 guideline update for Diagnosis & management of CHF in the Adult -SA Hunt
More informationUpdate on pharmacological treatment of heart failure. Aldo Pietro Maggioni, MD, FESC ANMCO Research Center Firenze, Italy
Update on pharmacological treatment of heart failure Aldo Pietro Maggioni, MD, FESC ANMCO Research Center Firenze, Italy Presenter Disclosures Dr. Maggioni : Serving in Committees of studies sponsored
More information100 mg atenolol equivalent to metoprolol
100 mg atenolol equivalent to metoprolol Metoprolol is a selective beta-blocker at dosages usually prescribed to lower blood. For High Blood Pressure For 7 years I have been on 50 mg. of atenolol for.
More informationDrug Class Review on Calcium Channel Blockers FINAL REPORT
Drug Class Review on Calcium Channel Blockers FINAL REPORT September 2003 TABLE OF CONTENTS Introduction 5 Scope and Key Questions 6 Methods 6 Literature Search 6 Study Selection 6 Data Abstraction 7 Validity
More informationDatabase of Abstracts of Reviews of Effects (DARE) Produced by the Centre for Reviews and Dissemination Copyright 2017 University of York.
A comparison of the cost-effectiveness of five strategies for the prevention of non-steroidal anti-inflammatory drug-induced gastrointestinal toxicity: a systematic review with economic modelling Brown
More information10 years evaluation of soluble ST2 level and incidence of diastolic
10 years evaluation of soluble ST2 level and incidence of diastolic dysfunction in EGAT study population Wisuit Katekao, MD Prin Vathesatogkit, MD Oraporn See, MD Sukit Yamwong, MD Piyamitr Sritara, MD
More informationSystematic Reviews and Meta- Analysis in Kidney Transplantation
Systematic Reviews and Meta- Analysis in Kidney Transplantation Greg Knoll MD MSc Associate Professor of Medicine Medical Director, Kidney Transplantation University of Ottawa and The Ottawa Hospital KRESCENT
More information2014 PQRS OPTIONS FOR INDIVIDUAL MEASURES: REGISTRY ONLY
Measure #7 (NQF 0070): Coronary Artery Disease (CAD): Beta-Blocker Therapy Prior Myocardial Infarction (MI) or Left Ventricular Systolic Dysfunction (LVEF < 40%) 2014 PQRS OPTIONS F INDIVIDUAL MEASURES:
More informationBeta-blockers in Patients with Mid-range Left Ventricular Ejection Fraction after AMI Improved Clinical Outcomes
Beta-blockers in Patients with Mid-range Left Ventricular Ejection Fraction after AMI Improved Clinical Outcomes Seung-Jae Joo and other KAMIR-NIH investigators Department of Cardiology, Jeju National
More informationRIC Remote Ischemic Conditioning to reduce reperfusion injury during acute STEMI: A systematic review and meta-analysis
RIC Remote Ischemic Conditioning to reduce reperfusion injury during acute STEMI: A systematic review and meta-analysis [McLeod SL, Iansavitchene A, Cheskes S] Sheldon Cheskes, MD CCFP(EM) FCFP Medical
More informationIQWiG Reports - Commission No. A Ezetimibe for hypercholesterolaemia 1. Executive Summary
IQWiG Reports - Commission No. A10-02 Ezetimibe for hypercholesterolaemia 1 Executive Summary 1 Translation of the executive summary of the final report Ezetimib bei Hypercholesterinämie (Version 1.0;
More informationMeta-analyses: analyses:
Meta-analyses: analyses: how do they help, and when can they not? Lee Hooper Senior Lecturer in research synthesis & nutrition l.hooper@uea.ac.uk 01603 591268 Aims Systematic Reviews Discuss the scientific
More informationNeprilysin Inhibitor (Entresto ) Prior Authorization and Quantity Limit Program Summary
Neprilysin Inhibitor (Entresto ) Prior Authorization and Quantity Limit Program Summary FDA APPROVED INDICATIONS DOSAGE 1 Indication Entresto Reduce the risk of cardiovascular (sacubitril/valsartan) death
More informationTITLE: Acetylsalicylic Acid for Venous Thromboembolism Prophylaxis: A Review of Clinical Evidence, Benefits and Harms
TITLE: Acetylsalicylic Acid for Venous Thromboembolism Prophylaxis: A Review of Clinical Evidence, Benefits and Harms DATE: 23 August 2011 CONTEXT AND POLICY ISSUES: Thromboembolism occurs when a blood
More information12 th Annual Biomarkers in Heart Failure and Acute Coronary Syndromes: Diagnosis, Treatment and Devices. Heart Rate as a Cardiovascular Biomarker
12 th Annual Biomarkers in Heart Failure and Acute Coronary Syndromes: Diagnosis, Treatment and Devices Heart Rate as a Cardiovascular Biomarker Inder Anand, MD, FRCP, D Phil (Oxon.) Professor of Medicine,
More informationValidity and Reliability Study of the Thai Version of WHO Schedules for Clinical Assessment in Neuropsychiatry: Eating Disorders Section
Validity and Reliability Study of the Thai Version of WHO Schedules for Clinical Assessment in Neuropsychiatry: Eating Disorders Section Niramol Patjanasoontorn MD*, Suchat Paholpak MD*, Thawatchai Krisanaprakornkit
More informationUrate Lowering Efficacy of Febuxostat Versus Allopurinol in Hyperuricemic Patients with Gout
Philippine Journal of Internal Medicine Meta-Analysis Urate Lowering Efficacy of Febuxostat Versus Allopurinol in Hyperuricemic Patients with Gout Erika Bianca S. Villazor-Isidro, M.D.*; John Carlo G.
More informationBeta Blockade: Protection or Panacea
Beta Blockade: Protection or Panacea Jason Axt Jason s Recommendations Perioperative β Blockade (BB) If on BB stay on If Vascular Sx + documented ischemia - start. 2+ risk factors - start Use in isolated
More informationBeta-blockers: Now what? Annemarie Thompson, MD Assistant Professor of Anesthesia and Medicine Vanderbilt University Medical Center
Beta-blockers: Now what? Annemarie Thompson, MD Assistant Professor of Anesthesia and Medicine Vanderbilt University Medical Center Beta-blockers: What s known 30 Years 30 Careers Physician clarity regarding
More informationDefinition of Congestive Heart Failure
Heart Failure Definition of Congestive Heart Failure A clinical syndrome of signs & symptoms resulting from the heart s inability to supply adequate tissue perfusion. CHF Epidemiology Affects 4.7 million
More informationCADTH Therapeutic Review
Canadian Agency for Drugs and Technologies in Health Agence canadienne des médicaments et des technologies de la santé CADTH Therapeutic Review August 2012 Volume 1, Issue 1A Antithrombotic Therapy for
More informationVasodilation. Autoregulation ป จจ ยท ควบค มขนาดของหลอดเล อด. CO 2, H +, K +, lactate, adenosine osmolarity, temperature O 2
Regulation in cardiovascular system Local control/autoregulation of organs (brain and heart have higher priority) To provide adequate blood flow to tissue Central regulation To provide optimal blood pressure
More informationFattori condizionanti la sopravvivenza nel paziente con scompenso di cuore
Journal Club 13 Febbraio 2008 Fattori condizionanti la sopravvivenza nel paziente con scompenso di cuore Intissar Sleiman Prevalence of heart failure by sex and age (NHANES:1999-2004) Circulation 2007
More informationMonth/Year of Review: November 2014 Date of Last Review: June 2012 PDL Classes: Anti-anginals, Cardiovascular
Drug Use Research & Management Program Oregon State University, 500 Summer Street NE, E35, Salem, Oregon 97301-1079 Phone 503-947-5220 Fax 503-947-1119 Copyright 2012 Oregon State University. All Rights
More information2. The effectiveness of combined androgen blockade versus monotherapy.
Relative effectiveness and cost-effectiveness of methods of androgen suppression in the treatment of advanced prostate cancer Blue Cross and Blue Shield Association, Aronson N, Seidenfeld J Authors' objectives
More informationCholesterol lowering intervention for cardiovascular prevention in high risk patients with or without LDL cholesterol elevation
TrialResults-center.org www.trialresultscenter.org Cholesterol lowering intervention for cardiovascular prevention in high risk patients with or without LDL cholesterol elevation A systematic review and
More informationARCA biopharma. Investment Community Webcast: Top-line Data from GENETIC-AF Phase 2B Clinical Trial
ARCA biopharma Investment Community Webcast: Top-line Data from GENETIC-AF Phase 2B Clinical Trial February 26, 2018 Safe Harbor Statement This presentation contains "forward-looking statements" for purposes
More informationSchool of Dentistry. What is a systematic review?
School of Dentistry What is a systematic review? Screen Shot 2012-12-12 at 09.38.42 Where do I find the best evidence? The Literature Information overload 2 million articles published a year 20,000 biomedical
More informationReducing proteinuria
Date written: May 2005 Final submission: October 2005 Author: Adrian Gillin Reducing proteinuria GUIDELINES a. The beneficial effect of treatment regimens that include angiotensinconverting enzyme inhibitors
More informationCardiovascular Disease and Commercial Motor Vehicle Driver Safety. Physical Qualifications Division April 10, 2007
Federal Motor Carrier Safety Administration Executive Summary Cardiovascular Disease and Commercial Motor Vehicle Driver Safety Presented to Physical Qualifications Division April 10, 2007 Prepared by:
More informationAn example of a systematic review and meta-analysis
An example of a systematic review and meta-analysis Sattar N et al. Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials. Lancet 2010; 375: 735-742. Search strategy
More informationMINDFULNESS-BASED INTERVENTIONS IN EPILEPSY
03 March 2016; v.1 MINDFULNESS-BASED INTERVENTIONS IN EPILEPSY AIM This review aimed to evaluate the effectiveness of mindfulness as a therapeutic intervention for people with epilepsy. METHODS Criteria
More informationNew PINNACLE Measures The below measures for PINNACLE will be added as new measures to the outcomes reporting starting with Version 2.0.
New PINNACLE Measures The below measures for PINNACLE will be added as new measures to the outcomes reporting starting with Version 2.0. Measure Steward Measure Name Measure Description Rationale for Adding
More informationA patient with decompensated HF
A patient with decompensated HF Professor Michel KOMAJDA University Pierre & Marie Curie Pitie Salpetriere Hospital Department of Cardiology Paris (France) Declaration Of Interest 2010 Speaker : Servier,
More informationESC Guidelines for the Diagnosis and Treatment of Chronic Heart Failure
ESC Guidelines for the Diagnosis and Treatment of Chronic Heart Failure - 2005 Karl Swedberg Professor of Medicine Department of Medicine Sahlgrenska University Hospital/Östra Göteborg University Göteborg
More informationDISCLOSURES ACHIEVING SUCCESS THROUGH FAILURE: UPDATE ON HEART FAILURE WITH PRESERVED EJECTION FRACTION NONE
ACHIEVING SUCCESS THROUGH FAILURE: UPDATE ON HEART FAILURE WITH PRESERVED EJECTION FRACTION Lori M. Tam, MD Providence Heart Institute DISCLOSURES NONE 1 OUTLINE Systolic vs. Diastolic Heart Failure New
More informationAlcohol interventions in secondary and further education
National Institute for Health and Care Excellence Guideline version (Draft for Consultation) Alcohol interventions in secondary and further education NICE guideline: methods NICE guideline Methods
More informationIs Radical Prostatectomy in Thai Men a High Morbidity Surgery for Localized or Locally Advanced Prostate Cancer?
Is Radical Prostatectomy in Thai Men a High Morbidity Surgery for Localized or Locally Advanced Prostate Cancer? Sunai Leewansangtong MD*, Suchai Soontrapa MD*, Chaiyong Nualyong MD*, Sittiporn Srinualnad
More informationNational Horizon Scanning Centre. Irbesartan (Aprovel) for heart failure with preserved systolic function. August 2008
Irbesartan (Aprovel) for heart failure with preserved systolic function August 2008 This technology summary is based on information available at the time of research and a limited literature search. It
More informationPerioperative β blockers in patients having non-cardiac surgery: a meta-analysis
Perioperative β blockers in patients having non-cardiac surgery: a meta-analysis Sripal Bangalore, Jørn Wetterslev, Shruthi Pranesh, Sabrina Sawhney, Christian Gluud, Franz H Messerli Summary Background
More informationPosition Statement on ALDOSTERONE ANTAGONIST THERAPY IN CHRONIC HEART FAILURE
Position Statement on ALDOSTERONE ANTAGONIST THERAPY IN CHRONIC HEART FAILURE Over 8,000 patients have been studied in two well-designed placebo-controlled outcome-driven clinical trials to evaluate the
More informationCodes for a Medicare claims-based model to predict LVEF class- User Guide
Description and citation: This guide accompanies our manuscript [Desai RJ, Lin KJ, Patorno E, et al. Development and Preliminary Validation of a Medicare Claims Based Model to Predict Left Ventricular
More informationNoppachart Limpaphayom MD*, Vajara Wilairatana MD**
Randomized Controlled Trial between Surgery and Aspiration Combined with Methylprednisolone Acetate Injection plus Wrist Immobilization in the Treatment of Dorsal Carpal Ganglion Noppachart Limpaphayom
More information